Tereo®
Our unique manufacturing process
Tereo® unique processing
Tereo® is our patented manufacturing process, used to delicately process and effectively preserve human amniotic membrane in a dry and stable format.
The Tereo® process is a product of 15 years translational research from the University of Nottingham, Ophthalmology Department. Tereo® produces an allograft transplant with key attributes:
- High quality and safety for human application
- Standardised and consistent reproducible product
- Retention of key barrier function of amniotic membrane
- Easy to use and orientate
- Rapid and effective in-vivo rehydration
The Tereo® process preserves the natural integrity, quality, and function of fresh amniotic membrane
The process
The Tereo® process involves highly standardised and validated manufacturing process. Amongst others, core to Tereo® are the patented delicate spongy layer removal and evaporation dehydration processes.
This means Tereo processed amniotic membrane can be stored and shipped at between 2ºC and 25ºC with no need for freezing or preparation prior to application, ready to use when you need it.
Step 1
Care is taken to collect, transport and store fresh unprocessed amniotic tissue ensuring not to compromise the natural qualities and properties of the fresh tissue. Specific regions of the amniotic membrane are uniquely selected to ensure the final product is highly standardised.
Step 2
Amniotic membrane is carefully isolated from the placental tissues and subjected to a sequence of gentle washes to remove blood contamination.
Step 3
The spongy layer- the jelly-like stromal component – is carefully removed from the amniotic membrane using a patented process which is achieved without damaging the tissue.
Step 4
The amniotic membrane is aseptically processed to remove any potential remaining contaminants and treated to stabilise the tissue during dehydration.
Step 5
Amniotic membrane is delicately dehydrated using a patented low temperature vacuum evaporation process. This results in a stable, dry, standardised, minimally manipulated and highly malleable material – Omnigen®.
The result
Tereo processed amniotic membrane retains the natural structure and composition inherent to amniotic membrane and rehydrates using moisture on the surface of the eye. Once rehydrated, Tereo processed amniotic membrane has comparable integrity, quality, consistency to fresh amniotic membrane.
Once rehydrated, Tereo processed amniotic membrane is a comparable thickness to fresh amnion.
The benefits of Tereo processing
The clinical benefits of amniotic membrane in ophthalmology have been known for decades. However, challenges with tissue storage, logistics and accessibility, have restricted its use.
Tereo® processed amniotic membrane overcomes known challenges by retaining the natural integrity, and qualities of fresh amniotic membrane that aid ocular healing in an accessible and easy to use product.
- Improved retention of the amniotic membrane barrier function
- Stable on the shelf, storage between 2ºC to 25ºC for ease of access
- Rehydration in vivo
- Easy application and manipulation
- Protected integrity, quality, consistency, and function
